Monday, 20th August The Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology 2018

Chairs: Rory Clifton-Bligh & Christopher Yates
Presenter: Ann McCormack

Breakfast served from 6:45am

This conference acknowledges the sponsorship of

Chair: Bruce Robinson
Presenters: Liza Nery, Bruce Robinson & Duncan Topliss

Breakfast served from 6:45am

This conference acknowledges the sponsorship of

Warrick Inder (ESA President)
Chris O’Neill (SRB President)

This conference acknowledges the sponsorship of

• Actions and Interactions of Aldosterone and the Mineralocorticoid Receptor - Peter Fuller

This conference acknowledges the sponsorship of

• Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure. - Sabashini Ramchand

This conference acknowledges the sponsorship of

• A perspective of the contribution of my past research to current reproductive biology and medicine - David Whittingham
• Pushing the boundaries of biology and technology: A non-linear model with rewards and tensions - Alan Trounson
• Significant Advances in ART – under the “The clinical picture" - Rob Norman

• The GH, IGF-I Insulin axis - Aart Jan van der Lely
• Integrating pasireotide and pegvisomant into an acromegaly treatment algorithm - Morton Burt
• Growth Hormone Deficiency in Adults: Who and How to Treat - Ken Ho

This conference acknowledges the sponsorship of

• The prostate cancer sub-pathology intraductal carcinoma of the prostate is a high-risk feature of localised prostate cancer - Laura H Porter
• A role for the long non-coding RNA GHRLOS in cancer - Esha T Shah
• Ovarian hormones modulate the expression of genes involved in breast cancer diagnosis - Sarah M Bernhardt
• Periconceptional ethanol exposure results in altered behaviour and HPA activity in a rodent model. - Danielle J Burgess
• IRX4, a novel mediator of androgen receptor transcriptome in prostate cancer - Janaththani Panchadsaram
• Effect of sex and stage of menstrual cycle on cold- and meal-induced brown adipose tissue thermogenesis in humans - John-Paul Fuller-Jackson

• Mitochondrial functions during oocyte development: beyond ATP - Deepak Adhikari
• Accelerated ovarian reserve depletion has no effect on fertility in female Amh^-/- mice. - Michael W Pankhurst
• The oocyte-secreted factors GDF9, BMP15 and cumulin regulate inhibin and activin production in human granulosa cells - Dulama Richani
• The role of Semaphorin 7a during ovulation   - Kylie R Dunning
• Effects of different wavelengths of light at the same energy on the development of preimplantation embryos - Avishkar Saini
• Oocyte-secreted factors measured in serum of women correlate with reproductive potential - Angelique H Riepsamen

• Manipulating testicular androgen production to promote lifelong male health - Lee Smith
• Activin A target genes in fetal testis: clues to male infertility - Penny AF Whiley
• Sertoli cell proteins in testicular interstitial fluid; potential mediators of seminiferous tubule-interstitial cell communication - Liza O'Donnell
• Mechanistic insights into epididymosome-sperm interactions - Wei Zhou
• Seminal fluid may alter cytokine and chemokine gene expression in human endometrium after coitus - David J Sharkey
• Characterization of seminal plasma anti-HIV-1 antibodies - Kevin J Selva

This conference acknowledges the sponsorship of

• Living with the enemy: germ cell survival in the 21st century - Eileen McLaughlin

• Complications of Obesity in Men - Gary Wittert
• Androgen deprivation therapy for prostate cancer: mitigating adverse-effects. - Ada s Cheung
• Infertile update: male evaluation, management and outcome       - Rob McLachlan

This conference acknowledges the sponsorship of

• Chlamydia infection damages the ovary and depletes the ovarian reserve in mice   - Urooza Sarma
• The consequences of multigenerational exposure to acrylamide on DNA damage in the male germ line - Caitlin G Chambers
• The ovarian follicle reserve is preserved in inflammasome-deficient mice - Carolina Lliberos Requesens
• Investigation of intratesticular inflammatory responses in humans and mice implicates activin A as a potential inducer of fibrosis in the testis - Anastasia Christine Kleinert
• The effects of placental miRNAs predicted to target the placental renin-angiotensin system on trophoblast proliferation - Anya L Arthurs
• Sperm contribute to the maternal neutrophil and T cell responses in early mouse pregnancy - John E Schjenken
• DNA repair mechanisms responsible for safeguarding oocyte quality and offspring health - Jessica Stringer
• miR-29c overexpression in endometrial cancer reduced proliferation and increased apoptosis and altered cell cycle and migration related genes - Michelle Van Sinderen

• The effect of acute and chronic glucocorticoid exposure on the Thrombospondin-1:Osteocalcin ratio in humans - Warrick J Inder
• Human and mouse FGF9 mutations affect male sex determination - Brittany Croft
• Patients on dialysis have markedly abnormal cortical hip parameters by dual-energy X-ray absorptiometry - Jasna Aleksova
• Polymorphisms in the 5α-reductase gene (SRD5A2) modulate serum testosterone, dihydrotestosterone and sex hormone-binding globulin, and polymorphisms in the aromatase gene (CYP19A1) modulate serum estradiol and luteinising hormone in men - Bu B Yeap
• High-dose pre-thyroidectomy cholecalciferol reduces postoperative hypocalceamia when stratified by PTH status a randomized double blinded placebo-controlled trial - Jacqueline Hawthorne
• A liver mediated mechanism for loss of muscle mass during androgen deprivation therapy   - Teresa Lam
• Saline suppression test parameters may predict bilateral subtypes of primary aldosteronism. - Hikaru Hashimura

• Testosterone: The Biography of a Molecule - David Handelsman
• Advances in our understanding of male infertility over the past 50 years –shores of need and reefs of greed - R John Aitken
• Significant advances in male reproduction    - Rob McLachlan
• Targeted disruption of lipoxygenase enzymes to prevent oxidative stress-mediated pathologies in the male germline  - Elizabeth G Bromfield

This conference acknowledges the sponsorship of

• Highlights of placenta research past, present and future - Claire Roberts
• The Pathophysiology of Preeclampsia: 50 years of discovery but have we missed? - Kirsty G Pringle
• Understanding placental regulation of gestational diabetes and programmed disease - James SM Cuffe
• Therapeutic development for preeclampsia - Natalie Hannan

• KEEP CALM and CRISPR: joining the genome editing revolution - Paul Thomas

This conference acknowledges the sponsorship of

• Laser drilling for artificial shrinkage increases ROS levels in mouse blastocysts - Casidhe Goldsworthy
• Physiological oxygen facilitates the acquisition of a more embryonic stem cell-like metabolic response in human induced pluripotent stem cells - Alexandra J. Harvey
• Expression of olfactory signalling proteins in spermatozoa - Yuliya Makeyeva
•  Idebenone reduces mitochondrial ROS in mouse and human sperm with elevated baseline ROS - Victoria M Nikitaras

• Analysis of the Role of PRDM14 in Lineage Specification in the Mouse Preimplantation Embryo - Gulfam Ahmad
• Human multipotent NT2/D1 cells model bipotential events in mammalian sex determination - Vincent Harley
• The Roles of DNA Template Segregation in Cellular Differentiation in the Early Embryo - Erandhi M Liyanage
• Immunolocalisation of DNA Methylation and DNA methyltransferases In The Post-Implantation Mouse Embryo. - Romanthi J Madawala
• TETs exhibit cell-specific differential expression in response to steroid hormones in human endometrium - Vishakha Mahajan
• ESRP1 plays a role in gonadal cancer progression by regulation of alternative splicing  - Shaghayegh Saeidi
• ZFP708 mediates transgenerational epigenetic inheritance - Kay Yi Michelle Seah
• Expression of the neutral amino acid transporter B⁰AT1 (SLC6A19) in the mouse preimplantation embryo - Tamara Treleaven

• Sexually dimorphic requirement for FGFR2 expression in testicular and ovarian development - Brittany Croft
• Levels of oocyte-secreted BMP15 are altered by maternal age and polycystic ovaries in infertile patients - Adriana E Krysta
• Repeated mating progressively expands population size and suppressive capacity of regulatory T cells to build pregnancy tolerance in mice - Lachlan M Moldenhauer

• Seminal vesicle growth is stimulated by anti-leptin treatment in immature male mice - Mohammed A.K. Al-Aqbi
• To investigate sperm flagellar beating pattern in CRISP deficient mice - Avinash Gaikwad
• Mouse beta-defensin 22 contributes to male reproductive function and fertility - Ricky A Matias
• The fundamental role of both classical and backdoor pathways in male reproductive function - Diane Rebourcet
• The impact of environmental insult on the small RNA profile of spermatozoa - Natalie A Trigg
• What is the role of the testis in regulating epididymal activin levels? - Rukmali Wijayarathna

• Evolution of sperm shape and size in mice and rats - Bill Breed

• Mitochondrial distribution and trafficking is disrupted in oocytes from mitochondrial fission deficient and old mice - Jun Liu
• Measurement of mitochondrial distribution and membrane potential in oocytes - Usama Alzubaidi
• TGFβ-1 Regulation of Extracellular Matrix Genes in Cultured Primary Cells from the Bovine Theca Interna - Nicole A Bastian
• Defining the epigenetic origins of maternally inherited disease - Heidi Bildsoe
• The Role of Heparan Sulfate in Regulating Growth Differentiation Factor-9 (GDF-9) Signalling During Oocyte Maturation - Darren JX Chow
• Connecting the fetal and genetic origins of PCOS - Monica D Hartanti
• Determining the impacts of epigenetic modifying drugs on the female germline - Ellen Jarred
• Visualisation of oocyte mitochondria and transzonal projections using 3d quantification methods - David Kennedy
• The roles of TRAK2 and Miro in microtubule-mediated mitochondria dynamics in mammalian oocytes - In-Won Lee
• Loss of PUMA results in elevated primordial follicle reserves in adult mice and delays ovarian ageing - Seng Liew
• The potential role of haemoglobin in sequestering menadione-induced ROS during in vitro maturation of mouse cumulus-oocyte complexes - Megan Lim
• Oxidative damage is exacerbated by dysregulation of proteasomal activity in naturally aged oocytes - Bettina P Mihalas
• Nicotinamide enhances the developmental competence of porcine oocytes matured in vitro - Charley Pollard
• Dairy cows with high genetic merit for fertility produce better quality oocytes than those with low genetic merit for fertility - Charlotte B Reed
• A modified form of human GDF9 with cumulin-like Smad-2/3 activity - William A Stocker
• Incubation of cumulus-oocytes-complexes (COCs) from unstimulated mice with C-type natriuretic peptide (CNP) prior to in vitromaturation (IVM) did not improve outcomes compared to IVM alone   - Christie Sun
• Does exposure to ionising radiation damage mitochondria within oocytes? - Qiaochu Wang
• The dynamics of mitochondrial organisation during oocyte maturation - Wai Shan Yuen
• Cyclin A2 is necessary for the oocyte to embryo transition in mice - Qing-hua Zhang

• The effect of absent kisspeptin signalling on locomotor activity in mice. - Raj Patel
• Kisspeptin (Kp) and RFamide-related peptide 3 (RFRP-3) neurons in the hypothalamus of dairy cattle; expression of oestrogen receptor alpha (ERα), and inputs to gonadotrophin releasing hormone (GnRH) neurons. - Jessica Rose

• The effect of dietary protein content on reproductive physiology in mice - Peter K Ajuogu
• Characterisation of the glucocorticoid receptor isoform expression profile in the rat placenta and fetal liver in pregnancies exposed to periconceptional alcohol - Lisa K Akison
• Cardiovascular risk factors in offspring of preeclamptic pregnancies – systematic review and meta-analysis - Prabha Andraweera
• Cardiovascular risk factors in those born preterm – systematic review and meta-analysis - Prabha Andraweera
• Maternal corticosterone exposure in pregnant mice alters the expression of placental oxidative stress, antioxidant enzymes and mitochondrial content in a sex specific manner. - Lucy Bartho
• Combination sulfasalazine and metformin are additive in reducing placental secretion of antiangiogenic factor sFlt   - Fiona Brownfoot
• Advanced maternal age affects rat placental nutrient transport in a sex-specific manner - Alison S Care
• Periconceptional alcohol exposure alters female kidney function and circadian regulation of renal gene expression - Emily S Dorey
• Maternal Endothelium and Risk of Cardiovascular Diseases - Arooj Fatima
• The Effects of Maternal Melatonin Supplementation in Mid to Late Gestating Singleton and Twin-bearing Merino Ewes on Growth Parameters at Birth - Tom Flinn
• A murine model of IUGR induced by embryo transfer - Kathryn L Gatford
• Effects of conceptus sex and genetics on maternal circulating thyroid hormone and insulin-like growth factor concentrations - Stefan Hiendleder
• Dealing with the stress of preeclampsia through placental mitochondrial adaptations - Olivia J Holland
• Validation studies of a fluorescent method to measure placental glucose transport in mice - Harleen Kaur
• Elemental metabolomics in the characterisation of placental mitochondria in control and gestational diabetes mellitus - Daniel R McKeating
• Antenatal dexamethasone treatment in mice exerts reciprocal effects upon fetal and placental weight at E14.5 and E17.5 - Caitlin S Wyrwoll
• The effect of oestrous synchronisation and breed on anti-Mullerian hormone (AMH) concentrations in Merino and Suffolk ewes  - Jamee E Seccafien
• Linoleic acid alters inflammatory responses and increases reactive oxygen species generation in human trophoblast like cells - Nirajan Shrestha
• New insights into the regulation of uterine contractions in human labour - Ranga E Siriwardhana
• The Effects of Maternal Melatonin Supplementation on Blood Glucose and Thermoregulation in Neonatal Lambs - Alyce M Swinbourne
• Establishing an in-vivo magnetic resonance imaging (MRI) protocol for measurement of placental vascular function in rats - Yutthapong Tongpob

• Context is all - Characterisation of progesterone receptor-chromatin binding properties in mouse reproductive tissues and its implication of tissue-specific gene expression - Thao D Dinh

• Changes in proteomic profile of testicular interstitial fluid after short-term heat treatment in the adult rat - Rashid Aldahhan
• Exploring changes to protein homeostasis in the male germ line in response to oxidative stress - Shenae L Cafe
• The role of zinc transporters in male fertility - Lachlan Cauchi
• An orthodox samurai: KATNAL2 interacts with novel targets to co-ordinate manchette dynamics and sperm tail development - Jessica E.M Dunleavy
• Essential post-transcriptional regulators of germline maintenance and spermatogenesis - Robin M Hobbs
• Utilising RNA interference in Drosophila melanogaster to pre-screen for novel genes required for male fertility - Brendan J Houston
• Using focused ion beam scanning electron microscopy (FIB-SEM) tomography to define the three dimensional architecture of spermatogenesis - Denis Korneev
• Germ cell development in cryptorchid testes during first 18 month of life - Ruili Li
• Gene expression profiling of epigenetic chromatin modification enzymes, chromatin remodelling factors and ubiquitination enzymes in Dcaf17 knockout mouse testis - Bhavesh Mistry
• Investigating activin A effects on fetal male germ cell fate - Sarah C Moody
• Understanding poor chromatin compaction within human spermatozoa - Jacob Netherton
• The role of TOB1 in spermatogenesis: conservation of function in D.melanogaster and mice   - farnaz shapouri
• The role of the prorenin receptor in male fertility - Dagmar Wilhelm

• Prednisolone treatment in early pregnancy alters pregnancy outcomes in mice - Peck Y Chin
• The role of Wnt signalling in endometrial regeneration - James A Deane
• COBL: The regulator of microvillar length in uterine epithelial cells - Samson Dowland
• Endometrial miRNA profile varies with maternal age in a novel bovine model - Bethany J Finger
• Regulatory T cells protect against fetal loss in pregnancies compromised by peri-implantation disruption of progesterone signalling - Ella Green
• Macrophage depletion in the post-implantation phase elicits implantation failure through effects on the ovary and uterus in mice - Holly M Groome
• First trimester trophoblast cells induce regulatory properties in B cells - Ruth Marian Guzman-Genuino
• Defining and interrogating new protein markers of human endometrial receptivity: the epithelial ‘receptome’ - Jennifer Hutchison
• Rab13 is involved in the redistribution of desmosomes in uterine epithelial cells at the time of receptivity in the rat - Laura Lindsay
• Maternal ovarian hormones drive changes in the localisation and abundance of keratin 18 and keratin 19 intermediate filaments in uterine epithelial cells - Chad L Moore
• Furin cleaves the soluble prorenin receptor (s(P)RR) in BeWo choriocarcinoma cells but is it actually involved in syncytialisation? - Saije K Morosin
• A role for α -parvin and β -parvin in implantation and decidualisation during early pregnancy in the rat - Leigh Nicholson
• MicroRNA biogenesis machinery is dysregulated in the endometrium of infertile women suggesting a role in receptivity and infertility - Katarzyna Rainczuk
• Exposure to bisphenol A and 4-tert-octylphenol result in embryo implantation failure in mouse - Eui-Bae Jeung

• High-throughput screen identifies new non-hormonal contraceptive - Alaknanda Alaknanda
• Oxygen and acetyl-CoA modulate blastocyst H3K9 and H3K27 acetylation - Hannah M Burn
• The amount of L-proline in mouse preimplantation embyos - Margot L Day
• Understanding female fertility and taking control of reproductive health: preliminary data from a fertility knowledge survey - Emmalee A Ford
• Cumulus cell membrane integrity is rapidly lost at the time of cattle oocyte activation during time-lapse microscope imaging - Hanna J McLennan
• microRNA-223 mediated regulation of macrophages impacts lesion development in a mouse model of endometriosis - Kavita Panir
• Can hyperspectral microscopy detect metabolic variance in the cumulus oocyte complex and predict oocyte quality? - Cheow Yuen (Tiffany) Tan
• Lactate availability affects preimplantation mouse embryo acetylation and viability - Emma G Whatley